Quetiapine updated on 06-10-2025

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18403
R77666		 Kananen, 2023 Small for gestational age (ICD-10 diagnoses O36.5) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes 1.00 [0.43;2.33] 6/152   879/35,133 885 152
ref
S2456
R3128		 Vigod, 2015 Small for gestational age (birth weight < 3rd centile) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 1.12 [0.71;1.78] C 31/556   51/1,021 82 556
ref
Total 2 studies 1.09 [0.73;1.64] 967 708
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kananen, 2023Kananen, 2023 1.00[0.43; 2.33]88515223%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Vigod, 2015Vigod, 2015 1.12[0.71; 1.78]8255677%ROB confusion: unclearROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.09[0.73; 1.64]9677080.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.09[0.73; 1.64]9677080%NAKananen, 2023 Vigod, 2015 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.00[0.43; 2.33]885152 -NAKananen, 2023 1 unexposed, sickunexposed, sick 1.12[0.71; 1.78]82556 -NAVigod, 2015 1 Tags Adjustment   - No  - No 1.12[0.71; 1.78]82556 -NAVigod, 2015 1   - Yes  - Yes 1.00[0.43; 2.33]885152 -NAKananen, 2023 1 All studiesAll studies 1.09[0.73; 1.64]9677080%NAKananen, 2023 Vigod, 2015 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.00[0.43; 2.33]885152 -NAKananen, 2023 1 unexposed, sick controlsunexposed, sick controls 1.12[0.71; 1.78]82556 -NAVigod, 2015 10.510.01.0