Quetiapine updated on 06-10-2025

Large for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18403
R77667		 Kananen, 2023 Large for gestational age (ICD-10 diagnoses O36.§) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes 0.86 [0.34;2.17] 5/152   959/35,133 964 152
ref
S2456
R3130		 Vigod, 2015 Large for gestational age (> 97th centile) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 1.79 [0.99;3.24] C 22/556   23/1,021 45 556
ref
Total 2 studies 1.36 [0.68;2.72] 1,009 708
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kananen, 2023Kananen, 2023 0.86[0.34; 2.17]96415238%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Vigod, 2015Vigod, 2015 1.79[0.99; 3.24]4555662%ROB confusion: unclearROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 41% 1.36[0.68; 2.72]1,0097080.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.36[0.68; 2.72]1,00970841%NAKananen, 2023 Vigod, 2015 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.86[0.34; 2.17]964152 -NAKananen, 2023 1 unexposed, sickunexposed, sick 1.79[0.99; 3.24]45556 -NAVigod, 2015 1 Tags Adjustment   - No  - No 1.79[0.99; 3.24]45556 -NAVigod, 2015 1   - Yes  - Yes 0.86[0.34; 2.17]964152 -NAKananen, 2023 1 All studiesAll studies 1.36[0.68; 2.72]1,00970841%NAKananen, 2023 Vigod, 2015 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.86[0.34; 2.17]964152 -NAKananen, 2023 1 unexposed, sick controlsunexposed, sick controls 1.79[0.99; 3.24]45556 -NAVigod, 2015 10.510.01.0