Risperidone Paliperidone updated on 06-10-2025

Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2488
R3353		 Shechtman (Control exposed to Haloperidol), 2009 Withdrawal syndrome 3rd trimester prospective cohort exposed to other treatment, sick Adjustment: No 1.68 [0.48;5.90] C 8/71   4/57 12 71
ref
Total 1 studies 1.68 [0.48;5.90] 12 71
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Shechtman (Control exposed to Haloperidol), 2009Shechtman, 2009 1 1.68[0.48; 5.90]12710%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: unclearROB reporting: unclear0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control exposed to Haloperidol;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.68[0.48; 5.90]1271 -NAShechtman (Control exposed to Haloperidol), 2009 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 1.68[0.48; 5.90]1271 -NAShechtman (Control exposed to Haloperidol), 2009 1 Tags Adjustment   - No  - No 1.68[0.48; 5.90]1271 -NAShechtman (Control exposed to Haloperidol), 2009 1 All studiesAll studies 1.68[0.48; 5.90]1271 -NAShechtman (Control exposed to Haloperidol), 2009 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.68[0.48; 5.90]1271 -NAShechtman (Control exposed to Haloperidol), 2009 10.510.01.0