Risperidone Paliperidone updated on 06-10-2025

Neuro-developmental disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18362
R77416		 Bruno, 2024 Any neurodevelopmental disorder (cognitive, learning, language, ...) - Median follow-up: 6.7 years during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.68 [0.35;1.31] 9/294   3,823/197,296 3,832 294
ref
S12478
R46979		 Straub, 2022 Any neurodevelopmental disorder (ASD, ADHD, learning difficulty, language disorder, intellectual disability...) - By 8 years of age 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.03 [0.86;1.23] 143/1,404   156,357/3,309,095 156,500 1,404
ref
Total 2 studies 0.95 [0.69;1.31] 160,332 1,698
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bruno, 2024Bruno, 2024 0.68[0.35; 1.31]3,83229420%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Straub, 2022Straub, 2022 1.03[0.86; 1.23]156,5001,40480%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 29% 0.95[0.69; 1.31]160,3321,6980.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.95[0.69; 1.31]160,3321,69829%NABruno, 2024 Straub, 2022 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.03[0.86; 1.23]156,5001,404 -NAStraub, 2022 1 unexposed, sickunexposed, sick 0.68[0.35; 1.32]3,832294 -NABruno, 2024 1 Tags Adjustment   - Yes  - Yes 0.95[0.69; 1.31]160,3321,69829%NABruno, 2024 Straub, 2022 2 All studiesAll studies 0.95[0.69; 1.31]160,3321,69829%NABruno, 2024 Straub, 2022 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.03[0.86; 1.23]156,5001,404 -NAStraub, 2022 1 unexposed, sick controlsunexposed, sick controls 0.68[0.35; 1.32]3,832294 -NABruno, 2024 10.510.01.0