Risperidone Paliperidone updated on 06-10-2025

Gastroschisis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14306
R56435		 Huybrechts (Controls unexposed, NOS), 2023 Gastroschisis 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 1.44 [0.36;5.75]
excluded (control group) 		-/2,798   -/6,455,324 - 2,798
ref
S14307
R56447		 Huybrechts (Controls unexposed, sick), 2023 Gastroschisis 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 1.73 [0.43;6.91] -/2,270   -/318,731 - 2,270
ref
S2481
R3308		 Raguideau, 2017 Laparoschisis early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 7.56 [0.47;121.39] C 0/507   246/1,888,130 246 507
ref
Total 2 studies 2.32 [0.67;8.04] 246 2,777
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 1.73[0.43; 6.91]-2,27080%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Raguideau, 2017Raguideau, 2017 7.56[0.47; 121.39]24650720%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.32[0.67; 8.04]2462,7770.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.32[0.67; 8.04]2462,7770%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 7.56[0.47; 121.39]246507 -NARaguideau, 2017 1 unexposed, sickunexposed, sick 1.73[0.43; 6.94]-2,270 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - No  - No 7.56[0.47; 121.39]246507 -NARaguideau, 2017 1   - Yes  - Yes 1.73[0.43; 6.94]-2,270 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 2.32[0.67; 8.04]2462,7770%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14306

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.10[0.54; 8.16]2463,3059%NAHuybrechts (Controls unexposed, NOS), 2023 Raguideau, 2017 2 unexposed, sick controlsunexposed, sick controls 1.73[0.43; 6.94]-2,270 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0