Risperidone Paliperidone updated on 06-10-2025

Language disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18362
R77419		 Bruno, 2024 Language disorders/delay (ICD-10 codes F80.0–F80.2, in the absence of a hearing loss diagnosis) - Median follow-up: 6.7 years during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.82 [0.37;1.83] 6/294   1,773/163,604 1,779 294
ref
S12478
R46983		 Straub, 2022 Speech/language disorder (≥ 2 dates with ICD-9 Dx 315.3x (except 315.34)) - By 8 years of age 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.88 [0.66;1.19] 50/1,309   56,373/2,002,687 56,423 1,309
ref
Total 2 studies 0.87 [0.66;1.15] 58,202 1,603
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bruno, 2024Bruno, 2024 0.82[0.37; 1.83]1,77929412%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Straub, 2022Straub, 2022 0.88[0.66; 1.19]56,4231,30988%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.87[0.66; 1.15]58,2021,6030.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.87[0.66; 1.15]58,2021,6030%NABruno, 2024 Straub, 2022 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.88[0.66; 1.18]56,4231,309 -NAStraub, 2022 1 unexposed, sickunexposed, sick 0.82[0.37; 1.82]1,779294 -NABruno, 2024 1 Tags Adjustment   - Yes  - Yes 0.87[0.66; 1.15]58,2021,6030%NABruno, 2024 Straub, 2022 2 All studiesAll studies 0.87[0.66; 1.15]58,2021,6030%NABruno, 2024 Straub, 2022 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.88[0.66; 1.18]56,4231,309 -NAStraub, 2022 1 unexposed, sick controlsunexposed, sick controls 0.82[0.37; 1.82]1,779294 -NABruno, 2024 10.510.01.0