Risperidone Paliperidone updated on 06-10-2025

Learning disorders

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18362
R77418
Bruno, 2024 Learning disorders (ICD-10 codes F81.0–F81.9) - Median follow-up: 6.7 years during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.41 [0.10;1.63] -/294   1,304/163,604 - 294
ref
S12478
R46982
Straub, 2022 Learning difficulty ( ≥ 1 ICD-9 Dx 315.0x, 315.1, 315.2) - By 8 years of age 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.43 [0.66;3.10] -/-   5,489/2,002,687 - -
ref
Total 2 studies 0.88 [0.27;2.91] 0 294
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bruno, 2024Bruno, 2024 0.41[0.10; 1.63]-29439%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Straub, 2022Straub, 2022 1.43[0.66; 3.10]--61%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 58% 0.88[0.27; 2.91]-2940.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.88[0.27; 2.91]-29458%NABruno, 2024 Straub, 2022 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.43[0.66; 3.10]-- -NAStraub, 2022 1 unexposed, sickunexposed, sick 0.41[0.10; 1.66]-294 -NABruno, 2024 1 Tags Adjustment   - Yes  - Yes 0.88[0.27; 2.91]-29458%NABruno, 2024 Straub, 2022 2 All studiesAll studies 0.88[0.27; 2.91]-29458%NABruno, 2024 Straub, 2022 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.43[0.66; 3.10]5,480- -NAStraub, 2022 1 unexposed, sick controlsunexposed, sick controls Out of scale0.41[0.10; 1.66]1,295294 -NABruno, 2024 10.510.01.0