id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S18399 R77611 |
Chan (Controls exposed to FGA), 2024 | Cardiac malformations | at least 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No |
1.54 [0.32;7.40] C excluded (control group) |
2/69 8/420 | 10 | 69 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S18342 R77383 |
Chan (Controls unexposed, general pop), 2024 | Cardiac malformations | at least 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) excluded | Adjustment: Yes |
1.82 [0.17;40.46] excluded (control group) |
2/69 8,218/464,017 | 8,220 | 69 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S18396 R77601 |
Chan (Controls unexposed, sick), 2024 | Cardiac malformations | at least 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes | 1.28 [0.04;98.88] | 1/49 135/6,476 | 136 | 49 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S14306 R56429 |
Huybrechts (Controls unexposed, NOS), 2023 | Cardiovascular Malformations | 1st trimester | population based cohort retrospective | unexposed (general population or NOS) excluded | Adjustment: Yes |
0.95 [0.66;1.37] excluded (control group) |
-/2,798 -/6,455,324 | - | 2,798 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S14307 R56441 |
Huybrechts (Controls unexposed, sick), 2023 | Cardiovascular Malformations | 1st trimester | population based cohort retrospective | unexposed, sick | Adjustment: Yes | 0.99 [0.67;1.47] | -/2,270 -/318,731 | - | 2,270 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 2 studies | 0.99 [0.67;1.47] | 136 | 2,319 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Controls unexposed, sick; 2: Controls unexposed, sick;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 14306, 18399, 18342