Risperidone Paliperidone updated on 06-10-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18355
R77403		 Ishikawa, 2024 Miscarriage (4 - 22 weeks of gestation) during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes 0.84 [0.54;1.32] 26/112   44,092/176,323 44,118 112
ref
S3898
R8265		 Ozturk, 2016 Miscarriage during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: No 5.28 [0.21;135.02] C 0/2   15/261 15 2
ref
S2439
R3082		 Sorensen, 2015 Spontaneous abortion (< 22 weeks) early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.59 [1.12;2.25] 25/116   114,314/841,183 114,339 116
ref
S3902
R8272		 Yaris, 2005 Spontaneous abortions during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No 8.37 [0.32;219.24] C 0/2   9/248 9 2
ref
Total 4 studies 1.31 [0.72;2.38] 158,481 232
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ishikawa, 2024Ishikawa, 2024 0.84[0.54; 1.32]44,11811244%ROB confusion: moderateROB selection: moderateROB classification: criticalROB missing: criticalROB mesure: criticalROB reporting: moderate Ozturk, 2016Ozturk, 2016 5.28[0.21; 135.02]1523%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Sorensen, 2015Sorensen, 2015 1.59[1.12; 2.25]114,33911649%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Yaris, 2005Yaris, 2005 8.37[0.32; 219.24]923%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 57% 1.31[0.72; 2.38]158,4812320.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.64[1.16; 2.32]114,3631200%NAOzturk, 2016 Sorensen, 2015 Yaris, 2005 3 case control studiescase control studies 0.84[0.54; 1.31]44,118112 -NAIshikawa, 2024 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.31[0.72; 2.38]158,48123257%NAIshikawa, 2024 Ozturk, 2016 Sorensen, 2015 Yaris, 2005 4 Tags Adjustment   - No  - No 1.64[1.16; 2.32]114,3631200%NAOzturk, 2016 Sorensen, 2015 Yaris, 2005 3   - Yes  - Yes 0.84[0.54; 1.31]44,118112 -NAIshikawa, 2024 1 All studiesAll studies 1.31[0.72; 2.38]158,48123257%NAIshikawa, 2024 Ozturk, 2016 Sorensen, 2015 Yaris, 2005 40.220.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.94.21.9990.000Ishikawa, 2024Ozturk, 2016Sorensen, 2015Yaris, 2005

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.31[0.72; 2.38]158,48123257%NAIshikawa, 2024 Ozturk, 2016 Sorensen, 2015 Yaris, 2005 40.510.01.0