Risperidone Paliperidone updated on 06-10-2025

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3898
R8263		 Ozturk, 2016 Preterm birth (<37 weeks) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: No 9.31 [0.35;245.79] C 0/2   8/246 8 2
ref
S2458
R3146		 Vigod, 2015 Preterm birth <37 weeks gestation during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 0.93 [0.52;1.64] C 15/112   146/1,021 161 112
ref
S2475
R3213		 Newport, 2007 Preterm (<37 weeks estimated gestational age) late pregnancy prospective cohort exposed to other treatment, sick Adjustment: No 2.27 [0.04;129.96] C 0/6   0/13 0 6
ref
Total 3 studies 1.02 [0.57;1.83] 169 120
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ozturk, 2016Ozturk, 2016 9.31[0.35; 245.79]823%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Vigod, 2015Vigod, 2015 0.93[0.52; 1.64]16111295%ROB confusion: unclearROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Newport, 2007Newport, 2007 2.27[0.04; 129.96]062%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 1% 1.02[0.57; 1.83]1691200.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.02[0.57; 1.83]1691201%NAOzturk, 2016 Vigod, 2015 Newport, 2007 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 9.31[0.35; 245.79]82 -NAOzturk, 2016 1 unexposed, sickunexposed, sick 0.93[0.52; 1.64]161112 -NAVigod, 2015 1 exposed to other treatment, sickexposed to other treatment, sick 2.27[0.04; 129.96]-6 -NANewport, 2007 1 Tags Adjustment   - No  - No 1.02[0.57; 1.83]1691201%NAOzturk, 2016 Vigod, 2015 Newport, 2007 3 All studiesAll studies 1.02[0.57; 1.83]1691201%NAOzturk, 2016 Vigod, 2015 Newport, 2007 30.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 9.31[0.35; 245.79]82 -NAOzturk, 2016 1 unexposed, sick controlsunexposed, sick controls 0.93[0.52; 1.64]161112 -NAVigod, 2015 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.27[0.04; 129.96]-6 -NANewport, 2007 10.510.01.0