Ziprasidone updated on 06-10-2025

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14311
R56499		 Huybrechts (Controls unexposed, NOS), 2023 Major congenital malformations overall (excluding chromosomal abnormality) 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 1.12 [0.86;1.47]
excluded (control group) 		-/-   177,165/6,455,324 - -
ref
S14310
R56487		 Huybrechts (Controls unexposed, sick), 2023 Major congenital malformations overall (excluding chromosomal abnormality) 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 1.09 [0.81;1.46] -/-   11,647/318,731 - -
ref
Total 1 studies 1.09 [0.81;1.46] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 1.09[0.81; 1.46]--0%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.09[0.81; 1.46]-- -NAHuybrechts (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.09[0.81; 1.46]-- -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 1.09[0.81; 1.46]-- -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 1.09[0.81; 1.46]-- -NAHuybrechts (Controls unexposed, sick), 2023 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14311

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.12[0.86; 1.46]177,156- -NAHuybrechts (Controls unexposed, NOS), 2023 1 unexposed, sick controlsunexposed, sick controls 1.09[0.81; 1.46]11,638- -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0