id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S18401 R77648 |
Kernizan (Controls exposed to LTG), 2024 | Neonatal intensive care unit (NICU) admission | during pregnancy (anytime or not specified) | retrospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
0.71 [0.18;2.75] C excluded (control group) |
11/46 4/13 | 15 | 46 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S18348 R77394 |
Kernizan (Controls unexposed, sick), 2024 | Neonatal intensive care unit (NICU) admission | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, sick | Adjustment: No | 0.84 [0.39;1.81] C | 11/46 38/139 | 49 | 46 |
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S18338 R77367 |
Kulkarni - Quetiapine, 2024 | Neonatal Intensive Care Unit or Special Care Nursery admission | at least 1st trimester excluded | prospective cohort | unexposed, sick | Adjustment: No |
1.30 [0.46;3.62] C excluded (exposition period) |
20/44 9/23 | 29 | 44 |
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S18385 R77536 |
Kananen - Quetiapine, 2023 | Admission to neonatal intensive care unit (NICU) | during pregnancy (anytime or not specified) | retrospective cohort | unexposed (general population or NOS) | Adjustment: Yes | 1.13 [0.78;1.63] | 45/152 5,464/35,133 | 5,509 | 152 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S14268 R56086 |
Viguera b, 2023 | Admission to Neonatal Intensive Care Unit | during pregnancy (anytime or not specified) | prospective cohort | exposed to other treatment, sick | Adjustment: No | 0.76 [0.46;1.26] C | 34/193 42/191 | 76 | 193 |
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S14275 R56120 |
Heinonen b (Controls exposed to FGA), 2022 | Neonatal intensive care unit (NICU) admission | late pregnancy | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: No |
0.84 [0.62;1.13] C excluded (control group) |
208/972 73/297 | 281 | 972 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S14274 R56118 |
Heinonen b (Controls unexposed, NOS), 2022 | Neonatal intensive care unit (NICU) admission | late pregnancy | population based cohort retrospective | unexposed (general population or NOS) excluded | Adjustment: Yes |
1.80 [1.60;2.00] excluded (control group) |
208/972 98,976/1,262,047 | 99,184 | 972 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S14273 R56116 |
Heinonen b (Controls unexposed, sick), 2022 | Neonatal intensive care unit (NICU) admission | late pregnancy | population based cohort retrospective | unexposed, sick | Adjustment: Yes | 1.50 [1.30;1.70] | 208/972 4,010/34,492 | 4,218 | 972 |
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S3851 R8203 |
Ellfolk (Control exposed to FGA), 2019 | Neonatal care or intensive care unit | during pregnancy (anytime or not specified) | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: Yes |
0.93 [0.77;1.13] excluded (control group) |
990/4,204 335/1,564 | 1,325 | 4,204 |
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S3818 R8139 |
Ellfolk (Control unexposed), 2019 | Neonatal care or intensive care unit (NCU) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes | 1.46 [1.27;1.68] | 990/4,204 2,134/21,069 | 3,124 | 4,204 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S3905 R8278 |
Schaffer (Controls unexposed, NOS), 2019 | Admission to neonatal intensive care unit (NICU) or special care nursery | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) excluded | Adjustment: No |
2.68 [2.39;3.00] C excluded (control group) |
473/1,320 23,314/135,087 | 23,787 | 1,320 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S3907 R8287 |
Schaffer (Controls unexposed, sick), 2019 | Admission to neonatal intensive care unit (NICU) or special care nursery | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed, sick | Adjustment: No | 1.21 [1.03;1.42] C | 473/1,320 447/1,416 | 920 | 1,320 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2378 R2912 |
Frayne (Control exposed to antidepressants), 2018 | Moderate resuscitation | during pregnancy (anytime or not specified) | retrospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
0.54 [0.23;1.24] C excluded (control group) |
14/75 15/50 | 29 | 75 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2285 R2651 |
Frayne (Control unexposed, sick), 2018 | Moderate resuscitation | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, sick | Adjustment: No | 1.10 [0.45;2.70] C | 14/75 10/58 | 24 | 75 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2362 R2865 |
Sutter-Dallay, 2015 | Neonatal hospitalization | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, sick | Adjustment: Yes | 2.21 [1.16;4.21] | -/55 -/- | - | 55 |
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S2294 R8221 |
Vigod, 2015 | Neonatal respiratory distress syndrome | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes Matched | 0.82 [0.46;1.43] | 26/1,021 30/1,021 | 56 | 1,021 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2286 R2659 |
Sadowski, 2013 | Admitted in the neonatal intensive care unit (NICU) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, disease free | Adjustment: No Matched | 2.44 [1.13;5.28] C | 23/113 11/116 | 34 | 113 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2339 R2747 |
Newport, 2007 | Neonatal intensive care unit admission | late pregnancy | prospective cohort | exposed to other treatment, sick | Adjustment: No | 4.71 [0.25;89.85] C | 6/41 0/13 | 6 | 41 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 11 studies | 1.29 [1.11;1.51] | 14,016 | 8,192 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Controls unexposed, sick; 2: Controls unexposed, sick; 3: Control unexposed; 4: Controls unexposed, sick; 5: Control unexposed, sick;
Asymetry test p-value = 0.5272 (by Egger's regression)
slope=0.3564 (0.0917); intercept=-0.4620 (0.7023); t=0.6578; p=0.5272
excluded 2378, 3851, 3905, 14275, 14274, 18401