id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S18338 R77365 |
Kulkarni - Quetiapine, 2024 | Gestational diabetes mellitus | at least 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 3.46 [0.70;17.09] C | 11/46 2/24 | 13 | 46 |
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S14435 R57293 |
Wang b - HK cohort, 2021 | Gestational diabetes mellitus (GDM; using ICD code or a clinician reported GDM) | at least 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes | 1.04 [0.58;1.85] | 22/149 40/340 | 62 | 149 |
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S14433 R57292 |
Wang b - UK cohort, 2021 | Gestational diabetes mellitus (GDM; using Read Code classification or a recorded fasting plasma glucose level of 5.6 mmol/l or above or a 2-h plasma glucose level of 7.8 mmol/l or above) | at least 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes | 0.98 [0.51;1.88] | 14/349 40/1,577 | 54 | 349 |
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S3905 R8273 |
Schaffer (Controls unexposed, NOS), 2019 | Gestational diabetes | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) excluded | Adjustment: No |
1.80 [1.46;2.22] C excluded (control group) |
101/878 9,089/135,252 | 9,190 | 878 |
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S3907 R8282 |
Schaffer (Controls unexposed, sick), 2019 | Gestational diabetes | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed, sick | Adjustment: No | 1.79 [1.34;2.40] C | 101/878 96/1,419 | 197 | 878 |
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S3187 R5104 |
Park, 2018 | Gestational diabetes | at least 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes | 1.19 [0.95;1.50] | 206/2,872 318/7,507 | 524 | 2,872 |
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S2306 R2801 |
Panchaud, 2017 | Gestational diabetes mellitus | 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: Yes | 0.79 [0.40;1.56] | 33/303 16/149 | 49 | 303 |
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S2336 R2740 |
Petersen (Control discontinued treatment before pregnancy), 2016 | Gestational diabetes | 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: No | 0.88 [0.36;2.15] C | 9/280 11/302 | 20 | 280 |
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S2398 R3008 |
Petersen (Control unexposed, disease free), 2016 | Gestational diabetes | 1st trimester | retrospective cohort (claims database) | unexposed, disease free excluded | Adjustment: No |
1.99 [1.02;3.87] C excluded (control group) |
9/280 5,227/318,434 | 5,236 | 280 |
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S2329 R2698 |
Bellet - Aripiprazole, 2015 | Gestational diabetes | 1st trimester | prospective cohort | unexposed (general population or NOS) | Adjustment: No | 1.15 [0.33;4.04] | 4/86 7/172 | 11 | 86 |
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S2294 R3111 |
Vigod, 2015 | Gestational diabetes | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes Matched | 1.10 [0.77;1.57] | 64/923 62/1,021 | 126 | 923 |
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S2334 R2737 |
Hironaka (Control unexposed, disease free), 2011 | Gestational diabetes mellitus | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, disease free excluded | Adjustment: No |
10.84 [0.41;286.05] C excluded (control group) |
0/9 1/278 | 1 | 9 |
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S14447 R57308 |
Hironaka (Control unexposed, sick), 2011 | Gestational diabetes mellitus | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, sick | Adjustment: No | 0.29 [0.00;18.96] C | 0/9 0/3 | 0 | 9 |
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Total | 10 studies | 1.22 [1.01;1.47] | 1,056 | 5,895 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Controls unexposed, sick; 2: Control discontinued treatment before pregnancy; 3: Control unexposed, sick;
Asymetry test p-value = 0.4435 (by Egger's regression)
slope=0.3216 (0.1500); intercept=-0.5220 (0.6476); t=0.8062; p=0.4435
excluded 2334, 2398, 3905