Atypical antipsychotics (Second generation) updated on 06-10-2025

Cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12436
R46684
Anderson, 2020 Cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: No 2.50 [0.80;7.60] 4/16   1,539/12,863 1,543 16
ref
S2360
R2851
Raguideau, 2017 Cleft palate early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.35 [0.34;5.42] C 2/2,286   1,221/1,888,130 1,223 2,286
ref
Total 2 studies 1.96 [0.82;4.70] 2,766 2,302
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 2.50[0.80; 7.60]1,5431660%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Raguideau, 2017Raguideau, 2017 1.35[0.34; 5.42]1,2232,28640%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.96[0.82; 4.70]2,7662,3020.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.35[0.34; 5.42]1,2232,286 -NARaguideau, 2017 1 case control studiescase control studies 2.50[0.81; 7.71]1,54316 -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.96[0.82; 4.70]2,7662,3020%NAAnderson, 2020 Raguideau, 2017 2 Tags Adjustment   - No  - No 1.96[0.82; 4.70]2,7662,3020%NAAnderson, 2020 Raguideau, 2017 2 All studiesAll studies 1.96[0.82; 4.70]2,7662,3020%NAAnderson, 2020 Raguideau, 2017 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.96[0.82; 4.70]2,7662,3020%NAAnderson, 2020 Raguideau, 2017 20.510.01.0