Atypical antipsychotics (Second generation) updated on 06-10-2025

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12436
R46685		 Anderson, 2020 Cleft lip /− cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: No 0.90 [0.30;3.30] 3/15   3,035/14,359 3,038 15
ref
S2360
R2850		 Raguideau, 2017 Cleft lip with or without palate early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.48 [0.48;4.60] C 3/2,286   1,675/1,888,130 1,678 2,286
ref
Total 2 studies 1.17 [0.51;2.67] 4,716 2,301
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.90[0.30; 3.30]3,0381547%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Raguideau, 2017Raguideau, 2017 1.48[0.48; 4.60]1,6782,28653%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.17[0.51; 2.67]4,7162,3010.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.48[0.48; 4.60]1,6782,286 -NARaguideau, 2017 1 case control studiescase control studies 0.90[0.27; 2.98]3,03815 -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.17[0.51; 2.67]4,7162,3010%NAAnderson, 2020 Raguideau, 2017 2 Tags Adjustment   - No  - No 1.17[0.51; 2.67]4,7162,3010%NAAnderson, 2020 Raguideau, 2017 2 All studiesAll studies 1.17[0.51; 2.67]4,7162,3010%NAAnderson, 2020 Raguideau, 2017 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.17[0.51; 2.67]4,7162,3010%NAAnderson, 2020 Raguideau, 2017 20.510.01.0