Atypical antipsychotics (Second generation) updated on 06-10-2025

Atrial septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12436
R46681		 Anderson, 2020 Atrial septal defect (secundum or NOS) 1st trimester case control unexposed (general population or NOS) Adjustment: No 1.30 [0.40;4.10] 4/16   2,914/14,372 2,918 16
ref
S2360
R2842		 Raguideau, 2017 Atrial septal defect early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 2.31 [1.24;4.31] C 10/2,286   3,582/1,888,130 3,592 2,286
ref
Total 2 studies 2.03 [1.18;3.52] 6,510 2,302
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.30[0.40; 4.10]2,9181622%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Raguideau, 2017Raguideau, 2017 2.31[1.24; 4.31]3,5922,28678%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.03[1.18; 3.52]6,5102,3020.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.31[1.24; 4.31]3,5922,286 -NARaguideau, 2017 1 case control studiescase control studies 1.30[0.41; 4.16]2,91816 -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.03[1.18; 3.52]6,5102,3020%NAAnderson, 2020 Raguideau, 2017 2 Tags Adjustment   - No  - No 2.03[1.18; 3.52]6,5102,3020%NAAnderson, 2020 Raguideau, 2017 2 All studiesAll studies 2.03[1.18; 3.52]6,5102,3020%NAAnderson, 2020 Raguideau, 2017 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.03[1.18; 3.52]6,5102,3020%NAAnderson, 2020 Raguideau, 2017 20.510.01.0