Atypical antipsychotics (Second generation) updated on 06-10-2025

Assisted deliveries (forceps, vacuum, ...)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18385
R77527
Kananen - Quetiapine, 2023 Vaginal, vacuum-assisted delivery during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes 0.69 [0.32;1.50] 7/152   2,415/35,133 2,422 152
ref
S2286
R8152
Sadowski, 2013 Forceps/vacuum used during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No Matched 0.61 [0.26;1.40] C 10/113   16/116 26 113
ref
Total 2 studies 0.65 [0.37;1.15] 2,448 265
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kananen - Quetiapine, 2023Kananen - Quetiapine, 2023 0.69[0.32; 1.50]2,42215254%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Sadowski, 2013Sadowski, 2013 0.61[0.26; 1.40]2611346%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.65[0.37; 1.15]2,4482650.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.65[0.37; 1.15]2,4482650%NAKananen - Quetiapine, 2023 Sadowski, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.65[0.37; 1.15]2,4482650%NAKananen - Quetiapine, 2023 Sadowski, 2013 2 Tags Adjustment   - No  - No 0.61[0.26; 1.40]26113 -NASadowski, 2013 1   - Yes  - Yes 0.69[0.32; 1.49]2,422152 -NAKananen - Quetiapine, 2023 1 MatchedMatched 0.61[0.26; 1.40]26113 -NASadowski, 2013 1 All studiesAll studies 0.65[0.37; 1.15]2,4482650%NAKananen - Quetiapine, 2023 Sadowski, 2013 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.65[0.37; 1.15]2,4482650%NAKananen - Quetiapine, 2023 Sadowski, 2013 20.510.01.0