Atypical antipsychotics (Second generation) updated on 06-10-2025

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14276
R56337		 Huybrechts (Controls unexposed, NOS), 2023 Anorectal Atresia/Stenosis 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 0.91 [0.49;1.69]
excluded (control group) 		-/21,751   -/6,455,324 - 21,751
ref
S14299
R56350		 Huybrechts (Controls unexposed, sick), 2023 Anorectal Atresia/Stenosis 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 0.99 [0.52;1.91] -/17,068   -/318,731 - 17,068
ref
S12436
R46686		 Anderson, 2020 Anorectal atresia/stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: No 2.80 [0.80;9.90] 3/15   1,028/12,486 1,031 15
ref
S2360
R2854		 Raguideau, 2017 Ano-rectal atresia early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 0.72 [0.04;11.51] C 0/2,286   574/1,888,130 574 2,286
ref
Total 3 studies 1.25 [0.65;2.39] 1,605 19,369
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 0.99[0.52; 1.91]-17,06871%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Anderson, 2020Anderson, 2020 2.80[0.80; 9.90]1,0311524%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Raguideau, 2017Raguideau, 2017 0.72[0.04; 11.51]5742,2865%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 10% 1.25[0.65; 2.39]1,60519,3690.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.97[0.52; 1.83]57419,3540%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 2 case control studiescase control studies 2.80[0.80; 9.85]1,03115 -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.22[0.71; 6.98]1,6052,3010%NAAnderson, 2020 Raguideau, 2017 2 unexposed, sickunexposed, sick 0.99[0.52; 1.90]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - No  - No 2.22[0.71; 6.98]1,6052,3010%NAAnderson, 2020 Raguideau, 2017 2   - Yes  - Yes 0.99[0.52; 1.90]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 1.25[0.65; 2.39]1,60519,36910%NAHuybrechts (Controls unexposed, sick), 2023 Anderson, 2020 Raguideau, 2017 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14276

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.22[0.58; 2.57]1,60524,05222%NAHuybrechts (Controls unexposed, NOS), 2023 Anderson, 2020 Raguideau, 2017 3 unexposed, sick controlsunexposed, sick controls 0.99[0.52; 1.90]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0