Atypical antipsychotics (Second generation) updated on 06-10-2025

Craniosynostosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12436
R46688		 Anderson, 2020 Craniosynostosis 1st trimester case control unexposed (general population or NOS) Adjustment: No 1.80 [0.50;6.50] 3/15   1,567/13,025 1,570 15
ref
S2360
R2863		 Raguideau, 2017 Craniosynostosis early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.06 [0.15;7.55] C 1/2,286   778/1,888,130 779 2,286
ref
Total 2 studies 1.54 [0.53;4.50] 2,349 2,301
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.80[0.50; 6.50]1,5701570%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Raguideau, 2017Raguideau, 2017 1.06[0.15; 7.55]7792,28630%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.54[0.53; 4.50]2,3492,3010.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.06[0.15; 7.55]7792,286 -NARaguideau, 2017 1 case control studiescase control studies 1.80[0.50; 6.49]1,57015 -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.54[0.53; 4.50]2,3492,3010%NAAnderson, 2020 Raguideau, 2017 2 Tags Adjustment   - No  - No 1.54[0.53; 4.50]2,3492,3010%NAAnderson, 2020 Raguideau, 2017 2 All studiesAll studies 1.54[0.53; 4.50]2,3492,3010%NAAnderson, 2020 Raguideau, 2017 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.54[0.53; 4.50]2,3492,3010%NAAnderson, 2020 Raguideau, 2017 20.510.01.0