Atypical antipsychotics (Second generation) updated on 06-10-2025

Oesophageal atresia with or without tracheo-oesophageal fistula

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14276
R56341
Huybrechts (Controls unexposed, NOS), 2023 Esophageal Disorder 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 0.33 [0.08;1.31]
excluded (control group)
-/21,751   -/6,455,324 - 21,751
ref
S14299
R56354
Huybrechts (Controls unexposed, sick), 2023 Esophageal Disorder 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 0.41 [0.10;1.65] -/17,068   -/318,731 - 17,068
ref
S2360
R2853
Raguideau, 2017 Oesophageal atresia early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 0.99 [0.06;15.81] C 0/2,286   418/1,888,130 418 2,286
ref
Total 2 studies 0.49 [0.14;1.71] 418 19,354
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 0.41[0.10; 1.65]-17,06880%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Raguideau, 2017Raguideau, 2017 0.99[0.06; 15.81]4182,28620%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.49[0.14; 1.71]41819,3540.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.49[0.14; 1.71]41819,3540%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.99[0.06; 15.81]4182,286 -NARaguideau, 2017 1 unexposed, sickunexposed, sick 0.41[0.10; 1.67]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - No  - No 0.99[0.06; 15.81]4182,286 -NARaguideau, 2017 1   - Yes  - Yes 0.41[0.10; 1.67]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 0.49[0.14; 1.71]41819,3540%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14276

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.41[0.12; 1.44]41824,0370%NAHuybrechts (Controls unexposed, NOS), 2023 Raguideau, 2017 2 unexposed, sick controlsunexposed, sick controls Out of scale0.41[0.10; 1.67]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0