Atypical antipsychotics (Second generation) updated on 06-10-2025

Gastroschisis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14276
R56338		 Huybrechts (Controls unexposed, NOS), 2023 Gastroschisis 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 1.45 [0.82;2.56]
excluded (control group) 		-/21,751   -/6,455,324 - 21,751
ref
S14299
R56351		 Huybrechts (Controls unexposed, sick), 2023 Gastroschisis 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 1.34 [0.70;2.58] -/17,068   -/318,731 - 17,068
ref
S12436
R46689		 Anderson, 2020 Gastroschisis 1st trimester case control unexposed (general population or NOS) Adjustment: No 2.10 [0.60;7.30] 3/15   1,398/12,856 1,401 15
ref
S2360
R2859		 Raguideau, 2017 Laparoschisis early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 3.36 [0.47;23.95] C 1/2,286   246/1,888,130 247 2,286
ref
Total 3 studies 1.58 [0.90;2.74] 1,648 19,369
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 1.34[0.70; 2.58]-17,06872%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Anderson, 2020Anderson, 2020 2.10[0.60; 7.30]1,4011520%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Raguideau, 2017Raguideau, 2017 3.36[0.47; 23.95]2472,2868%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.58[0.90; 2.74]1,64819,3690.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.47[0.79; 2.73]24719,3540%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 2 case control studiescase control studies 2.10[0.60; 7.32]1,40115 -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.40[0.84; 6.90]1,6482,3010%NAAnderson, 2020 Raguideau, 2017 2 unexposed, sickunexposed, sick 1.34[0.70; 2.57]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - No  - No 2.40[0.84; 6.90]1,6482,3010%NAAnderson, 2020 Raguideau, 2017 2   - Yes  - Yes 1.34[0.70; 2.57]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 1.58[0.90; 2.74]1,64819,3690%NAHuybrechts (Controls unexposed, sick), 2023 Anderson, 2020 Raguideau, 2017 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14276

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.63[0.98; 2.68]1,64824,0520%NAHuybrechts (Controls unexposed, NOS), 2023 Anderson, 2020 Raguideau, 2017 3 unexposed, sick controlsunexposed, sick controls 1.34[0.70; 2.57]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0