Atypical antipsychotics (Second generation) updated on 06-10-2025

Hydrocephaly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14276
R56339		 Huybrechts (Controls unexposed, NOS), 2023 Hydrocephalus 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 1.21 [0.74;1.97]
excluded (control group) 		-/21,751   -/6,455,324 - 21,751
ref
S14299
R56352		 Huybrechts (Controls unexposed, sick), 2023 Hydrocephalus 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 1.01 [0.58;1.79] -/17,068   -/318,731 - 17,068
ref
Total 1 studies 1.01 [0.57;1.77] 0 17,068
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 1.01[0.58; 1.79]-17,0680%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.01[0.57; 1.77]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.01[0.57; 1.77]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 1.01[0.57; 1.77]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 1.01[0.57; 1.77]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14276

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.21[0.74; 1.97]-21,751 -NAHuybrechts (Controls unexposed, NOS), 2023 1 unexposed, sick controlsunexposed, sick controls 1.01[0.57; 1.77]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0