Atypical antipsychotics (Second generation) updated on 06-10-2025

Genetic syndromes and microdeletions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12148
R44995		 Ellfolk (Controls exposed to FGA), 2021 Infant/ fetuses with genetic syndromes 1st trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.49 [0.24;1.01] C
excluded (control group) 		20/3,478   12/1,030 32 3,478
ref
S12146
R44975		 Ellfolk (Controls unexposed, NOS), 2021 Infant/ fetuses with genetic syndromes 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No Matched 0.91 [0.57;1.45] C 20/3,478   143/22,540 163 3,478
ref
Total 1 studies 0.91 [0.57;1.45] 163 3,478
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ellfolk (Controls unexposed, NOS), 2021Ellfolk, 2021 1 0.91[0.57; 1.45]1633,4780%ROB confusion: unclearROB selection: lowROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.91[0.57; 1.45]1633,478 -NAEllfolk (Controls unexposed, NOS), 2021 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.91[0.57; 1.45]1633,478 -NAEllfolk (Controls unexposed, NOS), 2021 1 Tags Adjustment   - No  - No 0.91[0.57; 1.45]1633,478 -NAEllfolk (Controls unexposed, NOS), 2021 1 MatchedMatched 0.91[0.57; 1.45]1633,478 -NAEllfolk (Controls unexposed, NOS), 2021 1 All studiesAll studies 0.91[0.57; 1.45]1633,478 -NAEllfolk (Controls unexposed, NOS), 2021 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12148

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.91[0.57; 1.45]1633,478 -NAEllfolk (Controls unexposed, NOS), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.49[0.24; 1.01]323,478 -NAEllfolk (Controls exposed to FGA), 2021 10.510.01.0