Atypical antipsychotics (Second generation) updated on 06-10-2025

Low Apgar score (< 7) (at 1 min)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3851
R8201
Ellfolk (Control exposed to FGA), 2019 Apgar 1 min 0–6 during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: Yes 0.99 [0.75;1.29]
excluded (control group)
409/4,204   142/1,564 551 4,204
ref
S3818
R8137
Ellfolk (Control unexposed), 2019 Apgar 1 min 0–6 during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.40 [1.15;1.70] 409/4,204   1,160/21,069 1,569 4,204
ref
S2378
R2915
Frayne (Control exposed to antidepressants), 2018 Apgar < 8 at 1 min during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.41 [0.18;0.91] C
excluded (control group)
15/75   19/50 34 75
ref
S2285
R2914
Frayne (Control unexposed, sick), 2018 Apgar < 8 at 1 min during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 1.07 [0.45;2.54] C 15/75   11/58 26 75
ref
Total 2 studies 1.38 [1.14;1.67] 1,595 4,279
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ellfolk (Control unexposed), 2019Ellfolk, 2019 1 1.40[1.15; 1.70]1,5694,20495%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: low Frayne (Control unexposed, sick), 2018Frayne, 2018 2 1.07[0.45; 2.54]26755%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.38[1.14; 1.67]1,5954,2790.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed; 2: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.38[1.14; 1.67]1,5954,2790%NAEllfolk (Control unexposed), 2019 Frayne (Control unexposed, sick), 2018 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.40[1.15; 1.70]1,5694,204 -NAEllfolk (Control unexposed), 2019 1 unexposed, sickunexposed, sick 1.07[0.45; 2.54]2675 -NAFrayne (Control unexposed, sick), 2018 1 Tags Adjustment   - No  - No 1.07[0.45; 2.54]2675 -NAFrayne (Control unexposed, sick), 2018 1   - Yes  - Yes 1.40[1.15; 1.70]1,5694,204 -NAEllfolk (Control unexposed), 2019 1 All studiesAll studies 1.38[1.14; 1.67]1,5954,2790%NAEllfolk (Control unexposed), 2019 Frayne (Control unexposed, sick), 2018 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2378, 3851

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.40[1.15; 1.70]1,5694,204 -NAEllfolk (Control unexposed), 2019 1 unexposed, sick controlsunexposed, sick controls 1.07[0.45; 2.54]2675 -NAFrayne (Control unexposed, sick), 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.69[0.29; 1.62]5854,27976%NAEllfolk (Control exposed to FGA), 2019 Frayne (Control exposed to antidepressants), 2018 20.510.01.0