Atypical antipsychotics (Second generation) updated on 06-10-2025

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18385
R77535
Kananen - Quetiapine, 2023 Low 5-min Apgar score (≤ 7) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes 1.05 [0.60;1.82] 15/152   1,609/35,133 1,624 152
ref
S3851
R8202
Ellfolk (Control exposed to FGA), 2019 Apgar 5 min 0–6 during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: Yes 0.81 [0.55;1.20]
excluded (control group)
212/-   38/- 250 -
ref
S3818
R8138
Ellfolk (Control unexposed), 2019 Apgar 5 min 0–6 during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.82 [1.38;2.39] 212/4,204   399/21,069 611 4,204
ref
S2378
R2917
Frayne (Control exposed to antidepressants), 2018 Apgar < 8 at 5 min during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.52 [0.15;1.82] C
excluded (control group)
5/75   6/50 11 75
ref
S2285
R2916
Frayne (Control unexposed, sick), 2018 Apgar < 8 at 5 min during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 0.96 [0.25;3.76] C 5/75   4/58 9 75
ref
Total 3 studies 1.43 [0.92;2.21] 2,244 4,431
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kananen - Quetiapine, 2023Kananen - Quetiapine, 2023 1.05[0.60; 1.82]1,62415234%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Ellfolk (Control unexposed), 2019Ellfolk, 2019 1 1.82[1.38; 2.39]6114,20457%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: low Frayne (Control unexposed, sick), 2018Frayne, 2018 2 0.96[0.25; 3.76]9759%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 44% 1.43[0.92; 2.21]2,2444,4310.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed; 2: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.43[0.92; 2.21]2,2444,43144%NAKananen - Quetiapine, 2023 Ellfolk (Control unexposed), 2019 Frayne (Control unexposed, sick), 2018 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.46[0.86; 2.48]2,2354,35667%NAKananen - Quetiapine, 2023 Ellfolk (Control unexposed), 2019 2 unexposed, sickunexposed, sick 0.96[0.25; 3.76]975 -NAFrayne (Control unexposed, sick), 2018 1 Tags Adjustment   - No  - No 0.96[0.25; 3.76]975 -NAFrayne (Control unexposed, sick), 2018 1   - Yes  - Yes 1.46[0.86; 2.48]2,2354,35667%NAKananen - Quetiapine, 2023 Ellfolk (Control unexposed), 2019 2 All studiesAll studies 1.43[0.92; 2.21]2,2444,43144%NAKananen - Quetiapine, 2023 Ellfolk (Control unexposed), 2019 Frayne (Control unexposed, sick), 2018 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2378, 3851

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.46[0.86; 2.48]2,2354,35667%NAKananen - Quetiapine, 2023 Ellfolk (Control unexposed), 2019 2 unexposed, sick controlsunexposed, sick controls 0.96[0.25; 3.76]975 -NAFrayne (Control unexposed, sick), 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.78[0.54; 1.13]261750%NAEllfolk (Control exposed to FGA), 2019 Frayne (Control exposed to antidepressants), 2018 20.510.01.0