Atypical antipsychotics (Second generation) updated on 06-10-2025

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3905
R8277		 Schaffer (Controls unexposed, NOS), 2019 Perinatal death (stillbirth or death within 28 days of birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) excluded Adjustment: No 1.45 [0.85;2.47] C
excluded (control group) 		14/1,016   1,288/135,137 1,302 1,016
ref
S3907
R8286		 Schaffer (Controls unexposed, sick), 2019 Perinatal death (stillbirth or death within 28 days of birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 1.40 [0.66;2.94] C 14/1,016   14/1,414 28 1,016
ref
Total 1 studies 1.40 [0.66;2.94] 28 1,016
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Schaffer (Controls unexposed, sick), 2019Schaffer, 2019 1 1.40[0.66; 2.94]281,0160%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.40[0.66; 2.94]281,016 -NASchaffer (Controls unexposed, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.40[0.66; 2.94]281,016 -NASchaffer (Controls unexposed, sick), 2019 1 Tags Adjustment   - No  - No 1.40[0.66; 2.94]281,016 -NASchaffer (Controls unexposed, sick), 2019 1 All studiesAll studies 1.40[0.66; 2.94]281,016 -NASchaffer (Controls unexposed, sick), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3905

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.45[0.85; 2.47]1,3021,016 -NASchaffer (Controls unexposed, NOS), 2019 1 unexposed, sick controlsunexposed, sick controls 1.40[0.66; 2.94]281,016 -NASchaffer (Controls unexposed, sick), 2019 10.510.01.0