Atypical antipsychotics (Second generation) updated on 06-10-2025

Low Apgar score (< 7) (NOS)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2334
R3594		 Hironaka (Control unexposed, disease free), 2011 Low Apgar score (< 7) at 1 or 5 min during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free excluded Adjustment: No 10.84 [0.41;286.05] C
excluded (control group) 		0/9   1/278 1 9
ref
S14447
R57310		 Hironaka (Control unexposed, sick), 2011 Low Apgar score (< 7) at 1 or 5 min during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 0.29 [0.00;18.96] C 0/9   0/3 0 9
ref
Total 1 studies 0.29 [0.00;18.96] 0 9
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hironaka (Control unexposed, sick), 2011Hironaka, 2011 1 0.29[0.00; 18.96]090%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.29[0.00; 18.96]-9 -NAHironaka (Control unexposed, sick), 2011 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.29[0.00; 18.96]-9 -NAHironaka (Control unexposed, sick), 2011 1 Tags Adjustment   - No  - No 0.29[0.00; 18.96]-9 -NAHironaka (Control unexposed, sick), 2011 1 All studiesAll studies 0.29[0.00; 18.96]-9 -NAHironaka (Control unexposed, sick), 2011 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2334

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale10.84[0.41; 286.05]19 -NAHironaka (Control unexposed, disease free), 2011 1 unexposed, sick controlsunexposed, sick controls Out of scale0.29[0.00; 18.96]-9 -NAHironaka (Control unexposed, sick), 2011 10.510.01.0