Atypical antipsychotics (Second generation) updated on 06-10-2025

Large head circumference for gestational age

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14514
R57697		 Boden - Olanzapine and/or clozapine, 2012 Large for gestational age (head circumference > 97.7th percentile) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 3.02 [1.60;5.71] 11/186   -/- - 186
ref
Total 1 studies 3.02 [1.60;5.71] 0 186
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Boden - Olanzapine and/or clozapine, 2012Boden - Olanzapine and/or clozapine, 2012 3.02[1.60; 5.71]-1860%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.02[1.60; 5.71]-186 -NABoden - Olanzapine and/or clozapine, 2012 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.02[1.60; 5.71]-186 -NABoden - Olanzapine and/or clozapine, 2012 1 Tags Adjustment   - Yes  - Yes 3.02[1.60; 5.71]-186 -NABoden - Olanzapine and/or clozapine, 2012 1 All studiesAll studies 3.02[1.60; 5.71]-186 -NABoden - Olanzapine and/or clozapine, 2012 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.02[1.60; 5.71]2186 -NABoden - Olanzapine and/or clozapine, 2012 10.510.01.0