Atypical antipsychotics (Second generation) updated on 06-10-2025

Neonatal intracranial hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2294
R8224		 Vigod, 2015 Neonatal intraventricular haemorrhage during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No Matched 1.33 [0.46;3.84] 8/1,021   6/1,021 14 1,021
ref
Total 1 studies 1.33 [0.46;3.84] 14 1,021
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vigod, 2015Vigod, 2015 1.33[0.46; 3.84]141,0210%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.33[0.46; 3.84]141,021 -NAVigod, 2015 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.33[0.46; 3.84]141,021 -NAVigod, 2015 1 Tags Adjustment   - No  - No 1.33[0.46; 3.84]141,021 -NAVigod, 2015 1 MatchedMatched 1.33[0.46; 3.84]141,021 -NAVigod, 2015 1 All studiesAll studies 1.33[0.46; 3.84]141,021 -NAVigod, 2015 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.33[0.46; 3.84]141,021 -NAVigod, 2015 10.510.01.0