Atypical antipsychotics (Second generation) updated on 06-10-2025

Severe cognitive developmental delay (Mental retardation) (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17090
R71456
Bruno - Quetiapine, 2024 Cognitive developmental disorders/delay (ICD-10 codes F70.0–F73.0) - Median follow-up: 6.7 years during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.72 [0.35;1.49] 10/3,894   869/197,296 879 3,894
ref
S12466
R53787
Straub, 2022 Intellectual disability (≥ 2 dates with ICD-9 Dx 317, 318.x, 319) - By 8 years of age 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.90 [0.51;1.57] 15/8,298   3,348/2,002,687 3,363 8,298
ref
Total 2 studies 0.83 [0.53;1.29] 4,242 12,192
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bruno - Quetiapine, 2024Bruno - Quetiapine, 2024 0.72[0.35; 1.49]8793,89438%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Straub, 2022Straub, 2022 0.90[0.51; 1.57]3,3638,29862%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.83[0.53; 1.29]4,24212,1920.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.83[0.53; 1.29]4,24212,1920%NABruno - Quetiapine, 2024 Straub, 2022 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.90[0.51; 1.58]3,3638,298 -NAStraub, 2022 1 unexposed, sickunexposed, sick 0.72[0.35; 1.49]8793,894 -NABruno - Quetiapine, 2024 1 Tags Adjustment   - Yes  - Yes 0.83[0.53; 1.29]4,24212,1920%NABruno - Quetiapine, 2024 Straub, 2022 2 All studiesAll studies 0.83[0.53; 1.29]4,24212,1920%NABruno - Quetiapine, 2024 Straub, 2022 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.90[0.51; 1.58]3,3638,298 -NAStraub, 2022 1 unexposed, sick controlsunexposed, sick controls 0.72[0.35; 1.49]8793,894 -NABruno - Quetiapine, 2024 10.510.01.0