Atypical antipsychotics (Second generation) updated on 06-10-2025

Psychomotor developmental disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12466
R46920
Straub, 2022 Developmental Coordination Disorder (≥ 2 dates with ICD-9 Dx 315.4) - By 8 years of age 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.08 [0.80;1.44] 61/9,390   11,849/3,309,095 11,910 9,390
ref
S2332
R2730
Peng, 2013 Developmental Quotient (< 85) - Bayley-III Motor scale - At 12 months of age throughout pregnancy prospective cohort unexposed, disease free Adjustment: No Matched 1.67 [0.52;5.36] C 8/76   5/76 13 76
ref
Total 2 studies 1.11 [0.83;1.47] 11,923 9,466
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Straub, 2022Straub, 2022 1.08[0.80; 1.44]11,9109,39094%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Peng, 2013Peng, 2013 1.67[0.52; 5.36]13766%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: lowROB reporting: moderate Total (2 studies) I2 = 0% 1.11[0.83; 1.47]11,9239,4660.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.11[0.83; 1.47]11,9239,4660%NAStraub, 2022 Peng, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.11[0.83; 1.47]11,9239,4660%NAStraub, 2022 Peng, 2013 2 Tags Adjustment   - No  - No 1.67[0.52; 5.36]1376 -NAPeng, 2013 1   - Yes  - Yes 1.08[0.80; 1.45]11,9109,390 -NAStraub, 2022 1 MatchedMatched 1.67[0.52; 5.36]1376 -NAPeng, 2013 1 All studiesAll studies 1.11[0.83; 1.47]11,9239,4660%NAStraub, 2022 Peng, 2013 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.11[0.83; 1.47]11,9239,4660%NAStraub, 2022 Peng, 2013 20.510.01.0