Atypical antipsychotics (Second generation) updated on 06-10-2025

Learning disorders

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17090
R71457		 Bruno - Quetiapine, 2024 Learning disorders (ICD-10 codes F81.0–F81.9) - Median follow-up: 6.7 years during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 1.17 [0.82;1.68] 36/3,894   1,304/163,604 1,340 3,894
ref
S12466
R46918		 Straub, 2022 Learning difficulty ( ≥ 1 ICD-9 Dx 315.0x, 315.1, 315.2) - By 8 years of age 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.05 [0.68;1.60] 28/9,390   6,417/3,309,095 6,445 9,390
ref
Total 2 studies 1.12 [0.85;1.47] 7,785 13,284
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bruno - Quetiapine, 2024Bruno - Quetiapine, 2024 1.17[0.82; 1.68]1,3403,89459%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Straub, 2022Straub, 2022 1.05[0.68; 1.60]6,4459,39041%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.12[0.85; 1.47]7,78513,2840.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.12[0.85; 1.47]7,78513,2840%NABruno - Quetiapine, 2024 Straub, 2022 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.05[0.68; 1.61]6,4459,390 -NAStraub, 2022 1 unexposed, sickunexposed, sick 1.17[0.82; 1.67]1,3403,894 -NABruno - Quetiapine, 2024 1 Tags Adjustment   - Yes  - Yes 1.12[0.85; 1.47]7,78513,2840%NABruno - Quetiapine, 2024 Straub, 2022 2 All studiesAll studies 1.12[0.85; 1.47]7,78513,2840%NABruno - Quetiapine, 2024 Straub, 2022 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.05[0.68; 1.61]6,4459,390 -NAStraub, 2022 1 unexposed, sick controlsunexposed, sick controls 1.17[0.82; 1.67]1,3403,894 -NABruno - Quetiapine, 2024 10.510.01.0