Atypical antipsychotics (Second generation) updated on 06-10-2025

Minor congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2341
R2753		 Habermann (Control exposed to FGA), 2013 Minor malformations 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.84 [0.38;1.86] C
excluded (control group) 		17/427   10/212 27 427
ref
S2385
R2931		 Habermann (Control unexposed, disease free), 2013 Minor malformations 1st trimester prospective cohort unexposed, disease free Adjustment: No 1.20 [0.66;2.18] C 17/453   32/1,014 49 453
ref
Total 1 studies 1.20 [0.66;2.18] 49 453
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Habermann (Control unexposed, disease free), 2013Habermann, 2013 1 1.20[0.66; 2.18]494530%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: low0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.20[0.66; 2.18]49453 -NAHabermann (Control unexposed, disease free), 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.20[0.66; 2.18]49453 -NAHabermann (Control unexposed, disease free), 2013 1 Tags Adjustment   - No  - No 1.20[0.66; 2.18]49453 -NAHabermann (Control unexposed, disease free), 2013 1 All studiesAll studies 1.20[0.66; 2.18]49453 -NAHabermann (Control unexposed, disease free), 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2341

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.20[0.66; 2.18]49453 -NAHabermann (Control unexposed, disease free), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.84[0.38; 1.86]27427 -NAHabermann (Control exposed to FGA), 2013 10.510.01.0