id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S18393 R77588 |
Chan (Controls exposed to FGA), 2024 | Nervous system malformations | at least 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No |
0.40 [0.08;2.06] C excluded (control group) |
2/419 5/420 | 7 | 419 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S18339 R77370 |
Chan (Controls unexposed, general pop), 2024 | Nervous system malformations | at least 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) excluded | Adjustment: Yes |
1.47 [0.15;21.60] excluded (control group) |
2/419 1,927/464,017 | 1,929 | 419 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S18392 R77582 |
Chan (Controls unexposed, sick), 2024 | Nervous system malformations | at least 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes | 2.92 [0.22;204.05] | 2/363 48/6,476 | 50 | 363 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S12148 R44997 |
Ellfolk (Controls exposed to FGA), 2021 | Central nervous system malformations (ICD-9; 740–742) | 1st trimester | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: Yes |
0.53 [0.12;2.29] excluded (control group) |
8/3,478 7/1,030 | 15 | 3,478 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S12146 R44977 |
Ellfolk (Controls unexposed, NOS), 2021 | Central nervous system malformations (ICD-9; 740–742) | 1st trimester | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes Matched | 0.44 [0.13;1.53] | 8/3,478 47/22,540 | 55 | 3,478 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2341 R2754 |
Habermann (Control exposed to FGA), 2013 | Malformations Nervous system | 1st trimester | prospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
2.49 [0.12;52.00] C excluded (control group) |
2/430 0/213 | 2 | 430 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2385 R2932 |
Habermann (Control unexposed, disease free), 2013 | Malformations Nervous system | 1st trimester | prospective cohort | unexposed, disease free | Adjustment: No | 4.73 [0.43;52.34] C | 2/430 1/1,014 | 3 | 430 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 3 studies | 1.24 [0.23;6.68] | 108 | 4,271 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Controls unexposed, sick; 2: Controls unexposed, NOS; 3: Control unexposed, disease free;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 2341, 12148, 18393, 18339