Atypical antipsychotics (Second generation) updated on 06-10-2025

Respiratory system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18393
R77589		 Chan (Controls exposed to FGA), 2024 Respiratory system malformations at least 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 3.02 [0.31;29.17] C
excluded (control group) 		3/419   1/420 4 419
ref
S18339
R77371		 Chan (Controls unexposed, general pop), 2024 Respiratory system malformations at least 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) excluded Adjustment: Yes 2.57 [0.34;44.66]
excluded (control group) 		3/419   1,234/464,017 1,237 419
ref
S18392
R77583		 Chan (Controls unexposed, sick), 2024 Respiratory system malformations at least 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes 0.85 [0.03;19.78] 1/363   24/6,476 25 363
ref
S12148
R44998		 Ellfolk (Controls exposed to FGA), 2021 Respiratory tract malformations (ICD-9; 748) 1st trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: Yes 0.15 [0.01;1.63] C
excluded (control group) 		1/3,478   2/1,030 3 3,478
ref
S12146
R44978		 Ellfolk (Controls unexposed, NOS), 2021 Respiratory tract malformations (ICD-9; 748) 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Matched 0.12 [0.01;2.11] 1/3,478   20/22,540 21 3,478
ref
Total 2 studies 0.27 [0.03;2.09] 46 3,841
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chan (Controls unexposed, sick), 2024Chan, 2024 1 0.85[0.03; 19.78]2536340%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Ellfolk (Controls unexposed, NOS), 2021Ellfolk, 2021 2 0.12[0.01; 2.11]213,47860%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.27[0.03; 2.09]463,8410.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.27[0.03; 2.09]463,8410%NAChan (Controls unexposed, sick), 2024 Ellfolk (Controls unexposed, NOS), 2021 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.12[0.01; 1.74]213,478 -NAEllfolk (Controls unexposed, NOS), 2021 1 unexposed, sickunexposed, sick 0.85[0.03; 21.83]25363 -NAChan (Controls unexposed, sick), 2024 1 Tags Adjustment   - Yes  - Yes 0.27[0.03; 2.09]463,8410%NAChan (Controls unexposed, sick), 2024 Ellfolk (Controls unexposed, NOS), 2021 2 MatchedMatched 0.12[0.01; 1.74]213,478 -NAEllfolk (Controls unexposed, NOS), 2021 1 All studiesAll studies 0.27[0.03; 2.09]463,8410%NAChan (Controls unexposed, sick), 2024 Ellfolk (Controls unexposed, NOS), 2021 20.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12148, 18393, 18339

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.58[0.03; 11.76]1,2583,89764%NAChan (Controls unexposed, general pop), 2024 Ellfolk (Controls unexposed, NOS), 2021 2 unexposed, sick controlsunexposed, sick controls 0.85[0.03; 21.83]25363 -NAChan (Controls unexposed, sick), 2024 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.69[0.04; 13.21]73,89769%NAChan (Controls exposed to FGA), 2024 Ellfolk (Controls exposed to FGA), 2021 20.510.01.0