Atypical antipsychotics (Second generation) updated on 06-10-2025

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14276
R56333		 Huybrechts (Controls unexposed, NOS), 2023 Oral Cleft 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 1.14 [0.83;1.58]
excluded (control group) 		-/21,751   -/6,455,324 - 21,751
ref
S14299
R56346		 Huybrechts (Controls unexposed, sick), 2023 Oral Cleft 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 1.23 [0.86;1.76] -/17,068   -/318,731 - 17,068
ref
S12436
R46682		 Anderson, 2020 Any orofacial cleft 1st trimester case control unexposed (general population or NOS) Adjustment: No 1.40 [0.60;3.70] 7/19   4,574/15,898 4,581 19
ref
Total 2 studies 1.25 [0.90;1.75] 4,581 17,087
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 1.23[0.86; 1.76]-17,06887%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Anderson, 2020Anderson, 2020 1.40[0.60; 3.70]4,5811913%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.25[0.90; 1.75]4,58117,0870.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.23[0.86; 1.76]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 1 case control studiescase control studies 1.40[0.56; 3.48]4,58119 -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.40[0.56; 3.48]4,58119 -NAAnderson, 2020 1 unexposed, sickunexposed, sick 1.23[0.86; 1.76]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - No  - No 1.40[0.56; 3.48]4,58119 -NAAnderson, 2020 1   - Yes  - Yes 1.23[0.86; 1.76]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 1.25[0.90; 1.75]4,58117,0870%NAHuybrechts (Controls unexposed, sick), 2023 Anderson, 2020 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14276

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.17[0.86; 1.58]4,58121,7700%NAHuybrechts (Controls unexposed, NOS), 2023 Anderson, 2020 2 unexposed, sick controlsunexposed, sick controls 1.23[0.86; 1.76]-17,068 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0