Atypical antipsychotics (Second generation) updated on 06-10-2025

Urinary malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18393
R77590		 Chan (Controls exposed to FGA), 2024 Urinary malformations at least 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.83 [0.25;2.75] C
excluded (control group) 		5/419   6/420 11 419
ref
S18339
R77372		 Chan (Controls unexposed, general pop), 2024 Urinary malformations at least 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) excluded Adjustment: Yes 1.56 [0.38;7.72]
excluded (control group) 		5/419   3,783/464,017 3,788 419
ref
S18392
R77584		 Chan (Controls unexposed, sick), 2024 Urinary malformations at least 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes 1.33 [0.28;7.33] 4/363   67/6,476 71 363
ref
S2341
R2762		 Habermann (Control exposed to FGA), 2013 Malformations Kidney and urinary tract 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.49 [0.03;7.94] C
excluded (control group) 		1/430   1/213 2 430
ref
S2385
R2942		 Habermann (Control unexposed, disease free), 2013 Malformations Kidney and urinary tract 1st trimester prospective cohort unexposed, disease free Adjustment: No 0.79 [0.08;7.57] C 1/430   3/1,014 4 430
ref
Total 2 studies 1.11 [0.30;4.18] 75 793
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chan (Controls unexposed, sick), 2024Chan, 2024 1 1.33[0.28; 7.33]7136366%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Habermann (Control unexposed, disease free), 2013Habermann, 2013 2 0.79[0.08; 7.57]443034%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: low Total (2 studies) I2 = 0% 1.11[0.30; 4.18]757930.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Control unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.11[0.30; 4.18]757930%NAChan (Controls unexposed, sick), 2024 Habermann (Control unexposed, disease free), 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.79[0.08; 7.57]4430 -NAHabermann (Control unexposed, disease free), 2013 1 unexposed, sickunexposed, sick 1.33[0.26; 6.80]71363 -NAChan (Controls unexposed, sick), 2024 1 Tags Adjustment   - No  - No 0.79[0.08; 7.57]4430 -NAHabermann (Control unexposed, disease free), 2013 1   - Yes  - Yes 1.33[0.26; 6.80]71363 -NAChan (Controls unexposed, sick), 2024 1 All studiesAll studies 1.11[0.30; 4.18]757930%NAChan (Controls unexposed, sick), 2024 Habermann (Control unexposed, disease free), 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2341, 18393, 18339

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.26[0.36; 4.43]3,7928490%NAChan (Controls unexposed, general pop), 2024 Habermann (Control unexposed, disease free), 2013 2 unexposed, sick controlsunexposed, sick controls 1.33[0.26; 6.80]71363 -NAChan (Controls unexposed, sick), 2024 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.77[0.26; 2.30]138490%NAChan (Controls exposed to FGA), 2024 Habermann (Control exposed to FGA), 2013 20.510.01.0