id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S18393 R77591 |
Chan (Controls exposed to FGA), 2024 | Limb malformations | at least 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No |
3.05 [0.82;11.35] C excluded (control group) |
9/419 3/420 | 12 | 419 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S18339 R77373 |
Chan (Controls unexposed, general pop), 2024 | Limb malformations | at least 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) excluded | Adjustment: Yes |
2.68 [0.81;11.66] excluded (control group) |
9/419 4,661/464,017 | 4,670 | 419 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S18392 R77585 |
Chan (Controls unexposed, sick), 2024 | Limb malformations | at least 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes | 2.41 [0.74;9.97] | 9/363 77/6,476 | 86 | 363 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S12148 R45002 |
Ellfolk (Controls exposed to FGA), 2021 | Musculoskeletal malformations (ICD-9; 754.3–754.8, 755) | 1st trimester | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: Yes |
0.67 [0.32;1.38] excluded (control group) |
43/3,478 20/1,030 | 63 | 3,478 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S12146 R44982 |
Ellfolk (Controls unexposed, NOS), 2021 | Musculoskeletal malformations (ICD-9; 754.3–754.8, 755) | 1st trimester | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes Matched | 0.95 [0.58;1.57] | 43/3,478 234/22,540 | 277 | 3,478 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2341 R2758 |
Habermann (Control exposed to FGA), 2013 | Malformations Musculoskeletal system | 1st trimester | prospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
0.93 [0.13;6.63] C excluded (control group) |
2/230 2/213 | 4 | 230 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2385 R2938 |
Habermann (Control unexposed, disease free), 2013 | Malformations Musculoskeletal system | 1st trimester | prospective cohort | unexposed, disease free | Adjustment: No | 1.18 [0.22;6.47] C | 2/430 4/1,014 | 6 | 430 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 3 studies | 1.08 [0.69;1.69] | 369 | 4,271 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Controls unexposed, sick; 2: Controls unexposed, NOS; 3: Control unexposed, disease free;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 2341, 12148, 18393, 18339