Atypical antipsychotics (Second generation) updated on 06-10-2025

Therapeutic terminations of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12148
R44994		 Ellfolk (Controls exposed to FGA), 2021 Elective termination of pregnancy due to fetal anomaly (ETOPFA) 1st trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.13 [0.03;0.49] C
excluded (control group) 		3/3,478   7/1,030 10 3,478
ref
S12146
R44974		 Ellfolk (Controls unexposed, NOS), 2021 Elective termination of pregnancy due to fetal anomaly (ETOPFA) 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No Matched 0.19 [0.06;0.61] C 3/3,478   100/22,540 103 3,478
ref
S12447
R46713		 Yakuwa, 2019 Therapeutic abortions 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 1.74 [1.02;2.99] C 16/404   100/4,330 116 404
ref
S2329
R2702		 Bellet - Aripiprazole, 2015 Therapeutic abortions 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 6.05 [0.24;150.00] 1/86   0/172 1 86
ref
S2305
R2681		 McKenna, 2005 Therapeutic abortion during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No Matched 8.22 [1.85;36.59] C 15/151   2/151 17 151
ref
Total 4 studies 1.65 [0.35;7.88] 237 4,119
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ellfolk (Controls unexposed, NOS), 2021Ellfolk, 2021 1 0.19[0.06; 0.61]1033,47828%ROB confusion: unclearROB selection: lowROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate Yakuwa, 2019Yakuwa, 2019 1.74[1.02; 2.99]11640432%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate Bellet - Aripiprazole, 2015Bellet - Aripiprazole, 2015 6.05[0.24; 150.00]18614%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: unclearROB reporting: moderate McKenna, 2005McKenna, 2005 8.22[1.85; 36.59]1715126%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (4 studies) I2 = 83% 1.65[0.35; 7.88]2374,1190.020.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.65[0.35; 7.88]2374,11983%NAEllfolk (Controls unexposed, NOS), 2021 Yakuwa, 2019 Bellet - Aripiprazole, 2015 McKenna, 2005 4 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.65[0.35; 7.88]2374,11983%NAEllfolk (Controls unexposed, NOS), 2021 Yakuwa, 2019 Bellet - Aripiprazole, 2015 McKenna, 2005 4 Tags Adjustment   - No  - No 1.65[0.35; 7.88]2374,11983%NAEllfolk (Controls unexposed, NOS), 2021 Yakuwa, 2019 Bellet - Aripiprazole, 2015 McKenna, 2005 4 MatchedMatched 1.22[0.03; 48.08]1203,62993%NAEllfolk (Controls unexposed, NOS), 2021 McKenna, 2005 2 All studiesAll studies 1.65[0.35; 7.88]2374,11983%NAEllfolk (Controls unexposed, NOS), 2021 Yakuwa, 2019 Bellet - Aripiprazole, 2015 McKenna, 2005 40.020.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.94.41.9710.000Ellfolk (Controls unexposed, NOS), 2021Yakuwa, 2019Bellet - Aripiprazole, 2015McKenna, 2005

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 12148

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.65[0.35; 7.88]2374,11983%NAEllfolk (Controls unexposed, NOS), 2021 Yakuwa, 2019 Bellet - Aripiprazole, 2015 McKenna, 2005 4 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.13[0.03; 0.49]103,478 -NAEllfolk (Controls exposed to FGA), 2021 10.510.01.0