Atypical antipsychotics (Second generation) updated on 06-10-2025

Very preterm (28 to 32 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3851
R8197
Ellfolk (Control exposed to FGA), 2019 Very preterm birth < 32 weeks during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: Yes 0.78 [0.41;1.47]
excluded (control group)
50/4,225   37/1,576 87 4,225
ref
S3818
R8134
Ellfolk (Control unexposed), 2019 Very preterm birth < 32 weeks during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.78 [0.45;1.32] 50/4,225   170/21,125 220 4,225
ref
S2294
R8217
Vigod, 2015 Preterm birth <32 weeks gestation during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes Matched 0.85 [0.53;1.36] 39/1,021   44/1,021 83 1,021
ref
Total 2 studies 0.82 [0.57;1.17] 303 5,246
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ellfolk (Control unexposed), 2019Ellfolk, 2019 1 0.78[0.45; 1.32]2204,22543%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: low Vigod, 2015Vigod, 2015 0.85[0.53; 1.36]831,02157%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.82[0.57; 1.17]3035,2460.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.82[0.57; 1.17]3035,2460%NAEllfolk (Control unexposed), 2019 Vigod, 2015 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.78[0.46; 1.34]2204,225 -NAEllfolk (Control unexposed), 2019 1 unexposed, sickunexposed, sick 0.85[0.53; 1.36]831,021 -NAVigod, 2015 1 Tags Adjustment   - Yes  - Yes 0.82[0.57; 1.17]3035,2460%NAEllfolk (Control unexposed), 2019 Vigod, 2015 2 MatchedMatched 0.85[0.53; 1.36]831,021 -NAVigod, 2015 1 All studiesAll studies 0.82[0.57; 1.17]3035,2460%NAEllfolk (Control unexposed), 2019 Vigod, 2015 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3851

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.78[0.46; 1.34]2204,225 -NAEllfolk (Control unexposed), 2019 1 unexposed, sick controlsunexposed, sick controls 0.85[0.53; 1.36]831,021 -NAVigod, 2015 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.78[0.41; 1.48]874,225 -NAEllfolk (Control exposed to FGA), 2019 10.510.01.0