Atypical antipsychotics (Second generation) updated on 06-10-2025

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2332
R2714		 Peng, 2013 Low birth weight (< 2500 g) throughout pregnancy prospective cohort unexposed, disease free Adjustment: No Matched 5.61 [1.19;26.52] C 10/76   2/76 12 76
ref
S2334
R2738		 Hironaka (Control unexposed, disease free), 2011 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free excluded Adjustment: No 1.15 [0.06;21.03] C
excluded (control group) 		0/9   13/278 13 9
ref
S14447
R57309		 Hironaka (Control unexposed, sick), 2011 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 0.29 [0.00;18.96] C 0/9   0/3 0 9
ref
S3849
R8179		 Lin (Control exposed to FGA), 2010 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.59 [0.59;4.31] C
excluded (control group) 		6/48   16/194 22 48
ref
S3848
R8175		 Lin (Control unexposed, disease free), 2010 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: No 2.26 [0.95;5.37] C
excluded (control group) 		6/48   207/3,480 213 48
ref
S2331
R2708		 Lin (Control unexposed, sick), 2010 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 1.71 [0.67;4.34] 6/48   41/454 47 48
ref
S2339
R2745		 Newport, 2007 Low birth weight (< 2500 g) late pregnancy prospective cohort exposed to other treatment, sick Adjustment: No 4.71 [0.25;89.85] C 6/41   0/13 6 41
ref
S2305
R3067		 McKenna, 2005 Low birth weight during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No Matched 4.89 [1.33;17.99] C 11/110   3/135 14 110
ref
Total 5 studies 2.78 [1.44;5.35] 79 284
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Peng, 2013Peng, 2013 5.61[1.19; 26.52]127618%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Hironaka (Control unexposed, sick), 2011Hironaka, 2011 1 0.29[0.00; 18.96]092%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Lin (Control unexposed, sick), 2010Lin, 2010 2 1.71[0.67; 4.34]474849%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Newport, 2007Newport, 2007 4.71[0.25; 89.85]6415%ROB confusion: criticalROB selection: unclearROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate McKenna, 2005McKenna, 2005 4.89[1.33; 17.99]1411025%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (5 studies) I2 = 0% 2.78[1.44; 5.35]792840.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick; 2: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.78[1.44; 5.35]792840%NAPeng, 2013 Hironaka (Control unexposed, sick), 2011 Lin (Control unexposed, sick), 2010 Newport, 2007 McKenna, 2005 5 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.17[1.91; 14.04]261860%NAPeng, 2013 McKenna, 2005 2 unexposed, sickunexposed, sick 1.57[0.63; 3.91]47570%NAHironaka (Control unexposed, sick), 2011 Lin (Control unexposed, sick), 2010 2 exposed to other treatment, sickexposed to other treatment, sick 4.71[0.25; 89.85]641 -NANewport, 2007 1 Tags Adjustment   - No  - No 4.45[1.77; 11.20]322360%NAPeng, 2013 Hironaka (Control unexposed, sick), 2011 Newport, 2007 McKenna, 2005 4   - Yes  - Yes 1.71[0.67; 4.35]4748 -NALin (Control unexposed, sick), 2010 1 MatchedMatched 5.17[1.91; 14.04]261860%NAPeng, 2013 McKenna, 2005 2 All studiesAll studies 2.78[1.44; 5.35]792840%NAPeng, 2013 Hironaka (Control unexposed, sick), 2011 Lin (Control unexposed, sick), 2010 Newport, 2007 McKenna, 2005 50.120.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-5.06.02.5510.000Peng, 2013Hironaka (Control unexposed, sick), 2011Lin (Control unexposed, sick), 2010Newport, 2007McKenna, 2005

Asymetry test p-value = 0.9901 (by Egger's regression)

slope=1.0110 (0.8558); intercept=0.0154 (1.1430); t=0.0135; p=0.9901

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 3849, 3848, 2334

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.07[1.62; 5.81]2522430%NAPeng, 2013 Hironaka (Control unexposed, disease free), 2011 Lin (Control unexposed, disease free), 2010 McKenna, 2005 4 unexposed, sick controlsunexposed, sick controls 1.57[0.63; 3.91]47570%NAHironaka (Control unexposed, sick), 2011 Lin (Control unexposed, sick), 2010 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.78[0.69; 4.57]28890%NALin (Control exposed to FGA), 2010 Newport, 2007 20.510.01.0