id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S18385 R77575 |
Kananen - Quetiapine, 2023 | Small for gestational age (ICD-10 diagnoses O36.5) | during pregnancy (anytime or not specified) | retrospective cohort | unexposed (general population or NOS) | Adjustment: Yes | 1.00 [0.43;2.33] | 6/152 879/35,133 | 885 | 152 |
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S12451 R46729 |
Heinonen a (Controls unexposed, NOS), 2022 | Small for gestational age ( Z-scores based on infant weight for gestational age and sex < − 2 standard deviations) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed (general population or NOS) excluded | Adjustment: Yes |
1.23 [0.96;1.57] excluded (control group) |
66/1,710 30,102/1,296,539 | 30,168 | 1,710 |
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S12450 R46726 |
Heinonen a (Controls unexposed, sick), 2022 | Small for gestational age ( Z-scores based on infant weight for gestational age and sex < − 2 standard deviations) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed, sick | Adjustment: Yes | 1.17 [0.91;1.50] | 66/1,710 929/34,492 | 995 | 1,710 |
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S12454 R46738 |
Wang a (Controls exposed to FGA), 2021 | Small for gestational age (birth weight <2 standard deviations below the mean for gestational age) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No |
0.55 [0.15;1.99] C excluded (control group) |
3/199 11/405 | 14 | 199 |
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S12453 R46734 |
Wang a (Controls unexposed, NOS), 2021 | Small for gestational age (birth weight <2 standard deviations below the mean for gestational age) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: No | 0.88 [0.28;2.76] C | 3/199 6,990/410,545 | 6,993 | 199 |
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S3851 R8195 |
Ellfolk (Control exposed to FGA), 2019 | Small for gestational age (birth weight of more than two standard deviations less than the sex- and length-of-gestation-specific national standards) | during pregnancy (anytime or not specified) | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: Yes |
0.82 [0.58;1.16] excluded (control group) |
223/4,225 96/1,576 | 319 | 4,225 |
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S3818 R8130 |
Ellfolk (Control unexposed), 2019 | Small for gestational age (birth weight of more than two standard deviations less than the sex- and length-of-gestation-specific national standards) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes | 1.02 [0.80;1.30] | 223/4,225 779/21,125 | 1,002 | 4,225 |
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S3905 R8279 |
Schaffer (Controls unexposed, NOS), 2019 | Small for gestational age (<10th percentile) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) excluded | Adjustment: No |
1.33 [1.15;1.55] C excluded (control group) |
213/1,322 17,013/135,252 | 17,226 | 1,322 |
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S3907 R8288 |
Schaffer (Controls unexposed, sick), 2019 | Small for gestational age (<10th percentile) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed, sick | Adjustment: No | 0.80 [0.65;0.97] C | 213/1,322 276/1,419 | 489 | 1,322 |
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S2329 R2697 |
Bellet - Aripiprazole, 2015 | Fetal growth retardation (weight < the 10th percentile for gestational age) | 1st trimester | prospective cohort | unexposed (general population or NOS) | Adjustment: No | 2.97 [1.23;7.16] | 12/63 11/150 | 23 | 63 |
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S2294 R8219 |
Vigod, 2015 | Small for gestational age <10th centile | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes Matched | 1.20 [0.97;1.50] | 206/1,021 179/1,021 | 385 | 1,021 |
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S2286 R2655 |
Sadowski, 2013 | Small for gestational age (<10th centile) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, disease free | Adjustment: No Matched | 1.38 [0.58;3.28] C | 13/113 10/116 | 23 | 113 |
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S3849 R8181 |
Lin (Control exposed to FGA), 2010 | Small for gestational age (birth weight < the 10th percentile for gestational age) | during pregnancy (anytime or not specified) | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: No |
0.78 [0.36;1.68] C excluded (control group) |
10/48 49/194 | 59 | 48 |
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S3848 R8177 |
Lin (Control unexposed, disease free), 2010 | Small for gestational age (birth weight < the 10th percentile for gestational age) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed, disease free excluded | Adjustment: No |
1.39 [0.69;2.81] C excluded (control group) |
10/48 553/3,480 | 563 | 48 |
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S2331 R2711 |
Lin (Control unexposed, sick), 2010 | Small for gestational age (birth weight < the 10th percentile for gestational age) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed, sick | Adjustment: Yes | 1.15 [0.55;2.41] | 10/48 92/454 | 102 | 48 |
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S2376 R2904 |
Newham (Control exposed to FGA), 2008 | Small for date (birth weight < 10th percentile for gestational age) | during pregnancy (anytime or not specified) | prospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
0.47 [0.09;2.47] C excluded (control group) |
2/25 7/45 | 9 | 25 |
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S2325 R2693 |
Newham (Control unexposed, disease free), 2008 | Small for date (birth weight < 10th percentile for gestational age) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, disease free | Adjustment: No | 8.33 [0.38;181.51] C | 2/25 0/38 | 2 | 25 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 10 studies | 1.09 [0.91;1.32] | 10,899 | 8,878 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Controls unexposed, sick; 2: Controls unexposed, NOS; 3: Control unexposed; 4: Controls unexposed, sick; 5: Control unexposed, sick; 6: Control unexposed, disease free;
Asymetry test p-value = 0.1515 (by Egger's regression)
slope=-0.1196 (0.1202); intercept=1.0989 (0.6932); t=1.5854; p=0.1515
excluded 2376, 3849, 3848, 3851, 3905, 12454, 12451