Atypical antipsychotics (Second generation) updated on 06-10-2025

Neonatal disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2336
R2742		 Petersen (Control discontinued treatment before pregnancy), 2016 Adverse birth outcomes ( a composite outcome of tremor, agitation, breathing and muscle tone problems, low Apgar score) 3rd trimester retrospective cohort (claims database) unexposed, sick Adjustment: No 1.14 [0.44;2.93] C 9/203   9/230 18 203
ref
S3847
R8173		 Petersen (Control exposed to FGA), 2016 Adverse birth outcome 3rd trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.90 [0.29;2.76] C
excluded (control group) 		9/203   5/102 14 203
ref
S2398
R3013		 Petersen (Control unexposed, disease free), 2016 Adverse birth outcomes (a composite outcome of tremor, agitation, breathing and muscle tone problems, low Apgar score) 3rd trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 1.80 [0.92;3.52] C
excluded (control group) 		9/203   5,290/210,966 5,299 203
ref
S2341
R2765		 Habermann (Control exposed to FGA), 2013 Postnatal disorders late pregnancy prospective cohort exposed to other treatment, sick excluded Adjustment: Yes 1.24 [0.57;2.73]
excluded (control group) 		37/237   22/102 59 237
ref
S2385
R2947		 Habermann (Control unexposed, disease free), 2013 Postnatal disorders late pregnancy prospective cohort unexposed, disease free Adjustment: Yes 6.24 [3.51;11.10] 37/237   43/1,014 80 237
ref
Total 2 studies 2.78 [0.53;14.70] 98 440
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Petersen (Control discontinued treatment before pregnancy), 2016Petersen, 2016 1 1.14[0.44; 2.93]1820347%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Habermann (Control unexposed, disease free), 2013Habermann, 2013 2 6.24[3.51; 11.10]8023753%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: low Total (2 studies) I2 = 89% 2.78[0.53; 14.70]984400.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control discontinued treatment before pregnancy; 2: Control unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.78[0.53; 14.70]9844089%NAPetersen (Control discontinued treatment before pregnancy), 2016 Habermann (Control unexposed, disease free), 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 6.24[3.51; 11.10]80237 -NAHabermann (Control unexposed, disease free), 2013 1 unexposed, sickunexposed, sick 1.14[0.44; 2.93]18203 -NAPetersen (Control discontinued treatment before pregnancy), 2016 1 Tags Adjustment   - No  - No 1.14[0.44; 2.93]18203 -NAPetersen (Control discontinued treatment before pregnancy), 2016 1   - Yes  - Yes 6.24[3.51; 11.10]80237 -NAHabermann (Control unexposed, disease free), 2013 1 All studiesAll studies 2.78[0.53; 14.70]9844089%NAPetersen (Control discontinued treatment before pregnancy), 2016 Habermann (Control unexposed, disease free), 2013 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2341, 3847, 2398

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.40[1.01; 11.46]5,37944087%NAPetersen (Control unexposed, disease free), 2016 Habermann (Control unexposed, disease free), 2013 2 unexposed, sick controlsunexposed, sick controls 1.14[0.44; 2.93]18203 -NAPetersen (Control discontinued treatment before pregnancy), 2016 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.12[0.59; 2.12]734400%NAPetersen (Control exposed to FGA), 2016 Habermann (Control exposed to FGA), 2013 20.510.01.0