Metoclopramide

Ventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3267
R5266		 Huybrechts, 2018 Ventricular septal defect 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: Yes 0.91 [0.77;1.08] 220/52,809   347/77,165 567 52,809
ref
S2397
R2986		 Pasternak, 2013 Ventricular septal defect 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.77 [0.60;1.00] 82/28,486   386/113,698 468 28,486
ref
Total 2 studies 0.86 [0.74;1.00] 1,035 81,295
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts, 2018Huybrechts, 2018 0.91[0.77; 1.08]56752,80967%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.77[0.60; 1.00]46828,48633%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 12% 0.86[0.74; 1.00]1,03581,2950.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.86[0.74; 1.00]1,03581,29512%NAHuybrechts, 2018 Pasternak, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.77[0.60; 0.99]46828,486 -NAPasternak, 2013 1 exposed to other treatment, sickexposed to other treatment, sick 0.91[0.77; 1.08]56752,809 -NAHuybrechts, 2018 1 Tags Adjustment   - Yes  - Yes 0.86[0.74; 1.00]1,03581,29512%NAHuybrechts, 2018 Pasternak, 2013 2 All studiesAll studies 0.86[0.74; 1.00]1,03581,29512%NAHuybrechts, 2018 Pasternak, 2013 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.77[0.60; 0.99]46828,486 -NAPasternak, 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.91[0.77; 1.08]56752,809 -NAHuybrechts, 2018 10.510.01.0