Metoclopramide

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2734
R13252		 McGarry (Control exposed to perphenazine), 1971 Neonatal death (NOS) late pregnancy randomized controlled trial exposed to other treatment, sick excluded Adjustment: Randomisation Intramuscular 0.25 [0.03;2.23] C
excluded (control group) 		1/196   4/197 5 196
ref
S2735
R13253		 McGarry (Unexposed control), 1971 Neonatal death (NOS) late pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Intramuscular 0.48 [0.04;5.39] C 1/196   2/191 3 196
ref
Total 1 studies 0.48 [0.04;5.39] 3 196
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF McGarry (Unexposed control), 1971McGarry, 1971 1 0.48[0.04; 5.39]31960%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 0.48[0.04; 5.39]3196 -NAMcGarry (Unexposed control), 1971 1 Type of controls unexposed, sickunexposed, sick 0.48[0.04; 5.39]3196 -NAMcGarry (Unexposed control), 1971 1 Tags Adjustment   - Randomisation  - Randomisation 0.48[0.04; 5.39]3196 -NAMcGarry (Unexposed control), 1971 1 IntramuscularIntramuscular 0.48[0.04; 5.39]3196 -NAMcGarry (Unexposed control), 1971 1 All studiesAll studies 0.48[0.04; 5.39]3196 -NAMcGarry (Unexposed control), 1971 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2734

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.48[0.04; 5.39]3196 -NAMcGarry (Unexposed control), 1971 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.25[0.03; 2.23]5196 -NAMcGarry (Control exposed to perphenazine), 1971 10.510.01.0