Metoclopramide

Eye, ear, face and neck malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3472
R6653		 Bérard, 2019 Eye, ear, face, and neck 1st trimester population based cohort propective unexposed (general population or NOS) Adjustment: Yes 0.98 [0.31;3.16] 3/939   578/179,106 581 939
ref
Total 1 studies 0.98 [0.31;3.13] 581 939
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard, 2019Bérard, 2019 0.98[0.31; 3.16]5819390%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.98[0.31; 3.13]581939 -NABérard, 2019 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.98[0.31; 3.13]581939 -NABérard, 2019 1 Tags Adjustment   - Yes  - Yes 0.98[0.31; 3.13]581939 -NABérard, 2019 1 All studiesAll studies 0.98[0.31; 3.13]581939 -NABérard, 2019 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.98[0.31; 3.13]581939 -NABérard, 2019 10.510.01.0