Metoclopramide

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3472
R6648		 Bérard, 2019 Major malformations 1st trimester population based cohort propective unexposed (general population or NOS) Adjustment: Yes 1.27 [1.03;1.57] 105/958   14,402/179,106 14,507 958
ref
S3267
R5263		 Huybrechts, 2018 Any congenital malformations 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: Yes 1.01 [0.95;1.06] 1,732/52,809   2,891/77,165 4,623 52,809
ref
S2404
R3057		 Ashkenazi-Hoffnung, 2013 Congenital malformations (NOS) at least 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 3.00 [0.12;77.03] C 1/28   0/27 1 28
ref
S2397
R2981		 Pasternak, 2013 Major birth defects 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.93 [0.86;1.02] 721/28,486   3,024/113,968 3,745 28,486
ref
S2395
R2973		 Matok, 2009 Major malformations 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.04 [0.89;1.21] 182/3,458   3,834/78,245 4,016 3,458
ref
S2393
R2964		 Berkovitch, 2002 Major malformations 1st trimester prospective cohort unexposed, disease free Adjustment: No Matched 0.91 [0.34;2.45] 7/158   8/164 15 158
ref
Total 6 studies 1.01 [0.94;1.10] 26,907 85,897
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard, 2019Bérard, 2019 1.27[1.03; 1.57]14,50795811%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Huybrechts, 2018Huybrechts, 2018 1.01[0.95; 1.06]4,62352,80940%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Ashkenazi-Hoffnung, 2013Ashkenazi-Hoffnung, 2013 3.00[0.12; 77.03]1280%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.93[0.86; 1.02]3,74528,48631%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Matok, 2009Matok, 2009 1.04[0.89; 1.21]4,0163,45817%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Berkovitch, 2002Berkovitch, 2002 0.91[0.34; 2.45]151581%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (6 studies) I2 = 42% 1.01[0.94; 1.10]26,90785,8970.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.01[0.94; 1.10]26,90785,89742%NABérard, 2019 Huybrechts, 2018 Ashkenazi-Hoffnung, 2013 Pasternak, 2013 Matok, 2009 Berkovitch, 2002 6 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.04[0.89; 1.21]22,28333,06062%NABérard, 2019 Pasternak, 2013 Matok, 2009 Berkovitch, 2002 4 exposed to other treatment, sickexposed to other treatment, sick 1.01[0.96; 1.07]4,62452,8370%NAHuybrechts, 2018 Ashkenazi-Hoffnung, 2013 2 Tags Adjustment   - No  - No 1.01[0.39; 2.59]161860%NAAshkenazi-Hoffnung, 2013 Berkovitch, 2002 2   - Yes  - Yes 1.02[0.93; 1.11]26,89185,71163%NABérard, 2019 Huybrechts, 2018 Pasternak, 2013 Matok, 2009 4 MatchedMatched 0.91[0.34; 2.44]15158 -NABerkovitch, 2002 1 All studiesAll studies 1.01[0.94; 1.10]26,90785,89742%NABérard, 2019 Huybrechts, 2018 Ashkenazi-Hoffnung, 2013 Pasternak, 2013 Matok, 2009 Berkovitch, 2002 60.210.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.93.91.9870.000Bérard, 2019Huybrechts, 2018Ashkenazi-Hoffnung, 2013Pasternak, 2013Matok, 2009Berkovitch, 2002

Asymetry test p-value = 0.4510 (by Egger's regression)

slope=-0.0274 (0.0450); intercept=0.6957 (0.8337); t=0.8344; p=0.4510

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.04[0.89; 1.21]22,28333,06062%NABérard, 2019 Pasternak, 2013 Matok, 2009 Berkovitch, 2002 4 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.01[0.96; 1.07]4,62452,8370%NAHuybrechts, 2018 Ashkenazi-Hoffnung, 2013 20.510.01.0