Metoclopramide

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3472
R6654		 Bérard, 2019 Circulatory (including heart) system 1st trimester population based cohort propective unexposed (general population or NOS) Adjustment: Yes 1.39 [0.96;2.02] 30/939   3,552/179,106 3,582 939
ref
S3267
R5261		 Huybrechts, 2018 Cardiac malformations 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: Yes 0.95 [0.85;1.06] 476/52,809   738/77,165 1,214 52,809
ref
Total 2 studies 1.10 [0.77;1.58] 4,796 53,748
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard, 2019Bérard, 2019 1.39[0.96; 2.02]3,58293939%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Huybrechts, 2018Huybrechts, 2018 0.95[0.85; 1.06]1,21452,80961%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 73% 1.10[0.77; 1.58]4,79653,7480.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.10[0.77; 1.58]4,79653,74873%NABérard, 2019 Huybrechts, 2018 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.39[0.96; 2.02]3,582939 -NABérard, 2019 1 exposed to other treatment, sickexposed to other treatment, sick 0.95[0.85; 1.06]1,21452,809 -NAHuybrechts, 2018 1 Tags Adjustment   - Yes  - Yes 1.10[0.77; 1.58]4,79653,74873%NABérard, 2019 Huybrechts, 2018 2 All studiesAll studies 1.10[0.77; 1.58]4,79653,74873%NABérard, 2019 Huybrechts, 2018 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.39[0.96; 2.02]3,582939 -NABérard, 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.95[0.85; 1.06]1,21452,809 -NAHuybrechts, 2018 10.510.01.0