Metoclopramide

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3267
R5262		 Huybrechts, 2018 Oral clefts 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: Yes 0.76 [0.55;1.04] 63/52,809   111/77,165 174 52,809
ref
Total 1 studies 0.76 [0.55;1.05] 174 52,809
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts, 2018Huybrechts, 2018 0.76[0.55; 1.04]17452,8090%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.76[0.55; 1.05]17452,809 -NAHuybrechts, 2018 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.76[0.55; 1.05]17452,809 -NAHuybrechts, 2018 1 Tags Adjustment   - Yes  - Yes 0.76[0.55; 1.05]17452,809 -NAHuybrechts, 2018 1 All studiesAll studies 0.76[0.55; 1.05]17452,809 -NAHuybrechts, 2018 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.76[0.55; 1.05]17452,809 -NAHuybrechts, 2018 10.510.01.0