Metoclopramide

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2404
R3050		 Ashkenazi-Hoffnung, 2013 Spontaneous abortion (1st trimester) at least 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 0.48 [0.04;5.63] C 1/29   2/29 3 29
ref
S2397
R3002		 Pasternak, 2013 Spontaneous abortion (< 22 weeks) early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.35 [0.33;0.38] 757/37,946   9,414/151,661 10,171 37,946
ref
S2393
R2962		 Berkovitch, 2002 Spontaneous abortions (NOS) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No Matched 0.80 [0.22;2.93] 4/175   5/175 9 175
ref
Total 3 studies 0.35 [0.33;0.38] 10,183 38,150
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ashkenazi-Hoffnung, 2013Ashkenazi-Hoffnung, 2013 0.48[0.04; 5.63]3290%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.35[0.33; 0.38]10,17137,946100%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Berkovitch, 2002Berkovitch, 2002 0.80[0.22; 2.93]91750%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 0.35[0.33; 0.38]10,18338,1500.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.35[0.33; 0.38]10,18338,1500%NAAshkenazi-Hoffnung, 2013 Pasternak, 2013 Berkovitch, 2002 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.41[0.22; 0.76]10,18038,12136%NAPasternak, 2013 Berkovitch, 2002 2 exposed to other treatment, sickexposed to other treatment, sick 0.48[0.04; 5.63]329 -NAAshkenazi-Hoffnung, 2013 1 Tags Adjustment   - No  - No 0.72[0.23; 2.25]122040%NAAshkenazi-Hoffnung, 2013 Berkovitch, 2002 2   - Yes  - Yes 0.35[0.33; 0.38]10,17137,946 -NAPasternak, 2013 1 MatchedMatched 0.80[0.22; 2.92]9175 -NABerkovitch, 2002 1 All studiesAll studies 0.35[0.33; 0.38]10,18338,1500%NAAshkenazi-Hoffnung, 2013 Pasternak, 2013 Berkovitch, 2002 30.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.41[0.22; 0.76]10,18038,12136%NAPasternak, 2013 Berkovitch, 2002 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.48[0.04; 5.63]329 -NAAshkenazi-Hoffnung, 2013 10.510.01.0